Introduction: Nasogastric feeding is effective and safe method for nutritional supply for patient who cannot fulfill nutritional requirement orally. However, several factors such as severe gastroesophageal reflux and gastroparesis interfere nasogastric feeding enough to satisfy nutritional requirement. Then, postpyloric feeding is effective alternative. There are several methods for inserting postpyloric feeding tube. This study was planned to investigate usefulness and safety of endoscopic postpyloric feeding tube insertion technique　for infant and children. Methods: Patients who underwent endoscopic post pyloric feeding tube insertion was recruited. We investigate demographic, anthropometric data, underlying diagnosis, the reason for insertion and data related to endoscopic feeding tube insertion. Results: Sixteen patients (11 boys and 5 girls) underwent 31 times of endoscopic post pyloric feeding tube insertion. Median age was 0.59 years (24 days to 16.0 years) and median body weight was 5.49 kg (2.1 to 84.0 kg). The reason for insertion was duodenal partial obstruction for 7 (43.8%). gastroparesis for 6 (37.5%), severe gastroesophageal reflux for 3 (8.8%). Thirteen patients (81.3%) underwent one time, two patients (12.5%) underwent two times and one patient (6.3%) underwent 13 times of procedures. Nine patients (56.3%) used tip-weighted enteral feeding tube for nasojejunal insertion and seven patients (43.8%) used tip-unweighted enteral feeding tube. The location of tube tip was duodenum for seven (22.6%) and jejunum for 24 (77.4%). Median maintenance period was 16 days (1 to 398 days). Median maintenance period was 4 days (1 to 71 days) in patients with tip-unweighted enteral tube with nasoduodenal location and 18.5 days (5 to 398 days) in tip-weighted enteral tube with nasojejunal location. The reason for remove was no need for further use for 13 (41.9%), pulling out against their will for 10 (32.3%), tube occlusion for 5 (16.1%), and tip migration for 3 (9.68%). Conclusions: Endoscopic postpyloric feeding tube insertion is effective, safe and feasible method for infant and children. Tip-weighted enteral feeding tube is effective for long stay use. Infant and child who need postpyloric feeding for long term use, endoscopic postpyloric feeding tube insertion with tip-weight enteral feeding tube can be a rational choice.